In 2013 Dr. Randy Schekman shared the Nobel Prize in Physiology or Medicine with James Rothman and Thomas Südhof. Today at TJU Dr. Schekman is giving a seminar today.
Dr. Randy Schekman is a Professor in the Department of Molecular and Cell Biology, University of California, Berkeley, and an Investigator of the Howard Hughes Medical Institute.
Schekman's laboratory investigates the mechanism of membrane protein traffic in the secretory pathway in eukaryotic cells. His approach began with a genetic and biochemical dissection of the secretory pathway in the yeast, S.cerevisiae. His lab discovered the genes and proteins that assemble proteins into the endoplasmic reticulum membrane, package proteins into coated (COPII) transport vesicles and deliver vesicles by fusion at a target membrane. The genes and proteins his lab discovered in yeast have counterparts in all eukaryotes and have been implicated in several human genetic diseases. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
The evolutionary conservation of the pathway discovered in Schekman's lab encouraged the biotechnology industry to use yeast as a platform for the production of clinically important human secreted proteins. Approximately one-third of the world supply of recombinant human insulin is made by secretion in yeast and the entire world supply of recombinant hepatitis b vaccine is made in vesicles produced in yeast. As hepatitis b infection is the major cause of liver cancer in the world, this vaccine promises to reduce the incidence of liver cancer by 90%. In recent years his lab has turned from yeast to mammalian cell culture to investigate aspects of human physiology and disease that are not readily studied in yeast. #gradlife#scienceexperiments#scientists#science#biologymajor#biochemistry#epigenetics#genes#genetics#biotechnolgy#probiotechnolgy#truth#research#medicine#innovation#cellbiology